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 2007-01-03 20:34:54 15548600     understanding of tubulogenesis and observed a robust induction of regulator of G protein signaling 4 ( RGS4 ) mRNA expression understand of tubulogenesis and observe a robust induction of RGS4 ( RGS4 ) mRNA expression  understanding of tubulogenesis understand of tubulogenesis</l> <ct name="/NounPhrase" s="324" l="13"> understanding</f> understand</l> </ct> <ct name="/BiologicalEntity" s="341" l="13"> tubulogenesis</f> tubulogenesis</l> <role name="Process" s="341" l="13"> tubulogenesis</f> tubulogenesis</l> </ct> <role name="INTER" s="359" l="8"> observed</f> observe</l> <role name="OBJ" s="368" l="79"> a robust induction of regulator of G protein signaling 4 ( RGS4 ) mRNA expression</f> a robust induction of RGS4 ( RGS4 ) mRNA expression</l> <role name="PROCESS" s="368" l="79"> a robust induction of regulator of G protein signaling 4 ( RGS4 ) mRNA expression</f> a robust induction of RGS4 ( RGS4 ) mRNA expression</l> <ct name="/Activation" s="377" l="9"> induction</f> induction</l> </ct> <role name="OBJ" s="390" l="57"> regulator of G protein signaling 4 ( RGS4 ) mRNA expression</f> <l>RGS4 ( RGS4 ) mRNA expression</l> <role name="PROCESS" s="390" l="57"> <f>regulator of G protein signaling 4 ( RGS4 ) mRNA expression</f> <l>RGS4 ( RGS4 ) mRNA expression</l> <role name="OBJ" s="390" l="46"> <f>regulator of G protein signaling 4 ( RGS4 ) mRNA</f> <l>RGS4 ( RGS4 ) mRNA</l> <ct name="/BiologicalEntity" s="390" l="46"> <f>regulator of G protein signaling 4 ( RGS4 ) mRNA</f> <l>RGS4 ( RGS4 ) mRNA</l> <role name="LabelledProteinGene" s="390" l="34"> <f>regulator of G protein signaling 4</f> <l>RGS4</l> <ct name="/ProMiner/human/ENTREZGENE/5999" s="390" l="34"> <f>regulator of G protein signaling 4</f> <l>RGS4</l> </ct> <ct name="/ProMiner/human/SWISSPROT/RGS4_HUMAN" s="390" l="34"> <f>regulator of G protein signaling 4</f> <l>RGS4</l> </ct> <role name="ProteinGene" s="425" l="6"> <f>( RGS4 )</f> <l>( RGS4 )</l> <role name="ChromosomalAndGenomicInformation" s="432" l="4"> <f>mRNA</f> <l>mRNA</l> </ct> <ct name="/GeneExpression" s="437" l="10"> <f>expression</f> <l>expression</l> </ct> <ct name="/CategoryActivationOfGeneExpression" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="504" l="38"> <f>a potential regulator of tubulogenesis</f> <l>a potential regulator of tubulogenesis</l> <role name="AGENT" s="504" l="38"> <f>a potential regulator of tubulogenesis</f> <l>a potential regulator of tubulogenesis</l> <ct name="/Regulation" s="516" l="9"> <f>regulator</f> <l>regulator</l> </ct> <ct name="/BiologicalEntity" s="529" l="13"> <f>tubulogenesis</f> <l>tubulogenesis</l> <role name="Process" s="529" l="13"> <f>tubulogenesis</f> <l>tubulogenesis</l> </ct> <ct name="/CategoryRegulation" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="557" l="60"> <f>RGS4 overexpression delayed and altered lung epithelial cell</f> <l>RGS4 overexpression delay and altered lung epithelial cell</l> <role name="PROCESS" s="557" l="19"> <f>RGS4 overexpression</f> <l>RGS4 overexpression</l> <role name="OBJ" s="557" l="4"> <f>RGS4</f> <l>RGS4</l> <ct name="/BiologicalEntity" s="557" l="4"> <f>RGS4</f> <l>RGS4</l> <role name="ProteinGene" s="557" l="4"> <f>RGS4</f> <l>RGS4</l> </ct> <ct name="/GeneExpression" s="562" l="14"> <f>overexpression</f> <l>overexpression</l> </ct> <role name="INTER" s="577" l="7"> <f>delayed</f> <l>delay</l> <role name="OBJ" s="589" l="28"> <f>altered lung epithelial cell</f> <l>altered lung epithelial cell</l> <ct name="/NounPhrase" s="589" l="12"> <f>altered lung</f> <l>altered lung</l> <ct name="/Regulation" s="589" l="7"> <f>altered</f> <l>altered</l> </ct> </ct> <ct name="/BiologicalEntity" s="613" l="4"> <f>cell</f> <l>cell</l> <role name="CellsAndTissues" s="613" l="4"> <f>cell</f> <l>cell</l> </ct> <ct name="/CategoryRegulation" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="905" l="28"> <f>reduction in VEGF expression</f> <l>reduction in VEGF expression</l> <role name="PROCESS" s="905" l="28"> <f>reduction in VEGF expression</f> <l>reduction in VEGF expression</l> <ct name="/Inhibition" s="905" l="9"> <f>reduction</f> <l>reduction</l> </ct> <role name="OBJ" s="918" l="15"> <f>VEGF expression</f> <l>VEGF expression</l> <role name="PROCESS" s="918" l="15"> <f>VEGF expression</f> <l>VEGF expression</l> <role name="OBJ" s="918" l="4"> <f>VEGF</f> <l>VEGF</l> <ct name="/BiologicalEntity" s="918" l="4"> <f>VEGF</f> <l>VEGF</l> <role name="ProteinGene" s="918" l="4"> <f>VEGF</f> <l>VEGF</l> </ct> <ct name="/GeneExpression" s="923" l="10"> <f>expression</f> <l>expression</l> </ct> <ct name="/CategoryNegationOfGeneExpression" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="951" l="70"> <f>overexpression of constitutively active MKK6, an activator of p38 MAPK</f> <l>overexpression of constitutively active MAP2K6, an activator of MAPK14 MAPK</l> <role name="PROCESS" s="951" l="44"> <f>overexpression of constitutively active MKK6</f> <l>overexpression of constitutively active MAP2K6</l> <ct name="/GeneExpression" s="951" l="14"> <f>overexpression</f> <l>overexpression</l> </ct> <role name="OBJ" s="969" l="26"> <f>constitutively active MKK6</f> <l>constitutively active MAP2K6</l> <ct name="/BiologicalEntity" s="991" l="4"> <f>MKK6</f> <l>MAP2K6</l> <role name="LabelledProteinGene" s="991" l="4"> <f>MKK6</f> <l>MAP2K6</l> <ct name="/ProMiner/human/ENTREZGENE/5608" s="991" l="4"> <f>MKK6</f> <l>MAP2K6</l> </ct> <ct name="/ProMiner/human/SWISSPROT/MP2K6_HUMAN" s="991" l="4"> <f>MKK6</f> <l>MAP2K6</l> </ct> </ct> <role name="AGENT" s="997" l="24"> <f>an activator of p38 MAPK</f> <l>an activator of MAPK14 MAPK</l> <ct name="/Activation" s="1000" l="9"> <f>activator</f> <l>activator</l> </ct> <ct name="/BiologicalEntity" s="1013" l="8"> <f>p38 MAPK</f> <l>MAPK14 MAPK</l> <role name="LabelledProteinGene" s="1013" l="3"> <f>p38</f> <l>MAPK14</l> <ct name="/ProMiner/human/ENTREZGENE/1432" s="1013" l="3"> <f>p38</f> <l>MAPK14</l> </ct> <ct name="/ProMiner/human/SWISSPROT/MK14_HUMAN" s="1013" l="3"> <f>p38</f> <l>MAPK14</l> </ct> </ct> <ct name="/CategoryGeneExpression" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="1034" l="67"> <f>RGS4 overexpression abrogated endothelial cell angiogenic sprouting</f> <l>RGS4 overexpression abrogate endothelial cell angiogenic sprout</l> <role name="PROCESS" s="1034" l="67"> <f>RGS4 overexpression abrogated endothelial cell angiogenic sprouting</f> <l>RGS4 overexpression abrogate endothelial cell angiogenic sprout</l> <role name="SUBJ" s="1034" l="19"> <f>RGS4 overexpression</f> <l>RGS4 overexpression</l> <role name="PROCESS" s="1034" l="19"> <f>RGS4 overexpression</f> <l>RGS4 overexpression</l> <role name="OBJ" s="1034" l="4"> <f>RGS4</f> <l>RGS4</l> <ct name="/BiologicalEntity" s="1034" l="4"> <f>RGS4</f> <l>RGS4</l> <role name="ProteinGene" s="1034" l="4"> <f>RGS4</f> <l>RGS4</l> </ct> <ct name="/GeneExpression" s="1039" l="14"> <f>overexpression</f> <l>overexpression</l> </ct> <role name="INTER" s="1054" l="9"> <f>abrogated</f> <l>abrogate</l> <ct name="/Inhibition" s="1054" l="9"> <f>abrogated</f> <l>abrogate</l> </ct> <role name="OBJ" s="1064" l="37"> <f>endothelial cell angiogenic sprouting</f> <l>endothelial cell angiogenic sprout</l> <ct name="/BiologicalEntity" s="1076" l="25"> <f>cell angiogenic sprouting</f> <l>cell angiogenic sprout</l> <role name="CellsAndTissues" s="1076" l="4"> <f>cell</f> <l>cell</l> </ct> <ct name="/CategoryGeneExpression" s="0" l="0"> <f/> <l/> </ct> <ct name="/CategoryInhibition" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="1211" l="61"> <f>RGS4 expression antagonized VEGF stimulation of DNA synthesis</f> <l>RGS4 expression antagonize VEGF stimulation of DNA synthesis</l> <role name="PROCESS" s="1211" l="61"> <f>RGS4 expression antagonized VEGF stimulation of DNA synthesis</f> <l>RGS4 expression antagonize VEGF stimulation of DNA synthesis</l> <role name="SUBJ" s="1211" l="15"> <f>RGS4 expression</f> <l>RGS4 expression</l> <role name="PROCESS" s="1211" l="15"> <f>RGS4 expression</f> <l>RGS4 expression</l> <role name="OBJ" s="1211" l="4"> <f>RGS4</f> <l>RGS4</l> <ct name="/BiologicalEntity" s="1211" l="4"> <f>RGS4</f> <l>RGS4</l> <role name="ProteinGene" s="1211" l="4"> <f>RGS4</f> <l>RGS4</l> </ct> <ct name="/GeneExpression" s="1216" l="10"> <f>expression</f> <l>expression</l> </ct> <role name="INTER" s="1227" l="11"> <f>antagonized</f> <l>antagonize</l> <ct name="/Inhibition" s="1227" l="11"> <f>antagonized</f> <l>antagonize</l> </ct> <role name="OBJ" s="1239" l="33"> <f>VEGF stimulation of DNA synthesis</f> <l>VEGF stimulation of DNA synthesis</l> <role name="PROCESS" s="1239" l="33"> <f>VEGF stimulation of DNA synthesis</f> <l>VEGF stimulation of DNA synthesis</l> <role name="OBJ" s="1239" l="4"> <f>VEGF</f> <l>VEGF</l> <ct name="/BiologicalEntity" s="1239" l="4"> <f>VEGF</f> <l>VEGF</l> <role name="ProteinGene" s="1239" l="4"> <f>VEGF</f> <l>VEGF</l> </ct> <ct name="/Activation" s="1244" l="11"> <f>stimulation</f> <l>stimulation</l> </ct> <ct name="/CategoryGeneExpression" s="0" l="0"> <f/> <l/> </ct> <ct name="/CategoryNegationOfActivation" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="1277" l="279"> <f>extracellular signal-regulated kinase ( ERK ) 1/ ERK2 and p38 MAPK activation as well as ERK1 / ERK2 activation stimulated by endothelin-1 and angiotensin II. RGS4 had no effect on the phosphorylation of Smad1 and Smad2 by bone morphogenic protein-7 and transforming growth factor-beta</f> <l>extracellular signal-regulated kinase ( ERK ) 1/ MAPK1 and MAPK14 MAPK activation as well as MAPK3 / MAPK1 activation stimulate by EDN1 and AGT II. RGS4 have no effect on the phosphorylation of Smad1 and SMAD2 by bone morphogenic protein-7 and TGFB1</l> <role name="RELATIONed" s="1277" l="157"> <f>extracellular signal-regulated kinase ( ERK ) 1/ ERK2 and p38 MAPK activation as well as ERK1 / ERK2 activation stimulated by endothelin-1 and angiotensin II. RGS4</f> <l>extracellular signal-regulated kinase ( ERK ) 1/ MAPK1 and MAPK14 MAPK activation as well as MAPK3 / MAPK1 activation stimulate by EDN1 and AGT II. RGS4</l> <role name="OBJ" s="1277" l="105"> <f>extracellular signal-regulated kinase ( ERK ) 1/ ERK2 and p38 MAPK activation as well as ERK1 / ERK2 activation</f> <l>extracellular signal-regulated kinase ( ERK ) 1/ MAPK1 and MAPK14 MAPK activation as well as MAPK3 / MAPK1 activation</l> <role name="RELATIONed" s="1277" l="105"> <f>extracellular signal-regulated kinase ( ERK ) 1/ ERK2 and p38 MAPK activation as well as ERK1 / ERK2 activation</f> <l>extracellular signal-regulated kinase ( ERK ) 1/ MAPK1 and MAPK14 MAPK activation as well as MAPK3 / MAPK1 activation</l> <ct name="/Regulation" s="1291" l="16"> <f>signal-regulated</f> <l>signal-regulated</l> </ct> <role name="OBJ" s="1308" l="63"> <f>kinase ( ERK ) 1/ ERK2 and p38 MAPK activation as well as ERK1 / ERK2</f> <l>kinase ( ERK ) 1/ MAPK1 and MAPK14 MAPK activation as well as MAPK3 / MAPK1</l> <role name="PROCESS" s="1308" l="63"> <f>kinase ( ERK ) 1/ ERK2 and p38 MAPK activation as well as ERK1 / ERK2</f> <l>kinase ( ERK ) 1/ MAPK1 and MAPK14 MAPK activation as well as MAPK3 / MAPK1</l> <role name="OBJ" s="1308" l="31"> <f>kinase ( ERK ) 1/ ERK2 and p38 MAPK</f> <l>kinase ( ERK ) 1/ MAPK1 and MAPK14 MAPK</l> <ct name="/BiologicalEntity" s="1308" l="18"> <f>kinase ( ERK ) 1/ ERK2</f> <l>kinase ( ERK ) 1/ MAPK1</l> <role name="ProteinGene" s="1308" l="14"> <f>kinase ( ERK ) 1/</f> <l>kinase ( ERK ) 1/</l> <role name="LabelledProteinGene" s="1322" l="4"> <f>ERK2</f> <l>MAPK1</l> <ct name="/ProMiner/human/ENTREZGENE/5594" s="1322" l="4"> <f>ERK2</f> <l>MAPK1</l> </ct> <ct name="/ProMiner/human/SWISSPROT/MK01_HUMAN" s="1322" l="4"> <f>ERK2</f> <l>MAPK1</l> </ct> </ct> <ct name="/BiologicalEntity" s="1331" l="8"> <f>p38 MAPK</f> <l>MAPK14 MAPK</l> <role name="LabelledProteinGene" s="1331" l="3"> <f>p38</f> <l>MAPK14</l> <ct name="/ProMiner/human/ENTREZGENE/1432" s="1331" l="3"> <f>p38</f> <l>MAPK14</l> </ct> <ct name="/ProMiner/human/SWISSPROT/MK14_HUMAN" s="1331" l="3"> <f>p38</f> <l>MAPK14</l> </ct> <role name="UnclassifiedBiologicalEntity" s="1335" l="4"> <f>MAPK</f> <l>MAPK</l> </ct> <ct name="/Activation" s="1340" l="10"> <f>activation</f> <l>activation</l> </ct> <ct name="/BiologicalEntity" s="1362" l="9"> <f>ERK1 / ERK2</f> <l>MAPK3 / MAPK1</l> <role name="LabelledProteinGene" s="1362" l="4"> <f>ERK1</f> <l>MAPK3</l> <ct name="/ProMiner/human/ENTREZGENE/5595" s="1362" l="4"> <f>ERK1</f> <l>MAPK3</l> </ct> <ct name="/ProMiner/human/SWISSPROT/MK03_HUMAN" s="1362" l="4"> <f>ERK1</f> <l>MAPK3</l> </ct> <role name="LabelledProteinGene" s="1367" l="4"> <f>ERK2</f> <l>MAPK1</l> <ct name="/ProMiner/human/ENTREZGENE/5594" s="1367" l="4"> <f>ERK2</f> <l>MAPK1</l> </ct> <ct name="/ProMiner/human/SWISSPROT/MK01_HUMAN" s="1367" l="4"> <f>ERK2</f> <l>MAPK1</l> </ct> </ct> <role name="OBJ" s="1372" l="10"> <f>activation</f> <l>activation</l> <ct name="/Activation" s="1372" l="10"> <f>activation</f> <l>activation</l> </ct> <role name="INTER" s="1383" l="13"> <f>stimulated by</f> <l>stimulate by</l> <ct name="/Activation" s="1383" l="10"> <f>stimulated</f> <l>stimulate</l> </ct> <role name="SUBJ" s="1397" l="37"> <f>endothelin-1 and angiotensin II. RGS4</f> <l>EDN1 and AGT II. RGS4</l> <ct name="/BiologicalEntity" s="1397" l="12"> <f>endothelin-1</f> <l>EDN1</l> <role name="LabelledProteinGene" s="1397" l="12"> <f>endothelin-1</f> <l>EDN1</l> <ct name="/ProMiner/human/ENTREZGENE/1906" s="1397" l="12"> <f>endothelin-1</f> <l>EDN1</l> </ct> <ct name="/ProMiner/human/SWISSPROT/EDN1_HUMAN" s="1397" l="12"> <f>endothelin-1</f> <l>EDN1</l> </ct> </ct> <ct name="/BiologicalEntity" s="1414" l="20"> <f>angiotensin II. RGS4</f> <l>AGT II. RGS4</l> <role name="LabelledProteinGene" s="1414" l="11"> <f>angiotensin</f> <l>AGT</l> <ct name="/ProMiner/human/ENTREZGENE/183" s="1414" l="11"> <f>angiotensin</f> <l>AGT</l> </ct> <ct name="/ProMiner/human/SWISSPROT/ANGT_HUMAN" s="1414" l="11"> <f>angiotensin</f> <l>AGT</l> </ct> </ct> <role name="INTER" s="1435" l="6"> <f>had no</f> <l>have no</l> <role name="OBJ" s="1442" l="114"> <f>effect on the phosphorylation of Smad1 and Smad2 by bone morphogenic protein-7 and transforming growth factor-beta</f> <l>effect on the phosphorylation of Smad1 and SMAD2 by bone morphogenic protein-7 and TGFB1</l> <role name="PROCESS" s="1442" l="114"> <f>effect on the phosphorylation of Smad1 and Smad2 by bone morphogenic protein-7 and transforming growth factor-beta</f> <l>effect on the phosphorylation of Smad1 and SMAD2 by bone morphogenic protein-7 and TGFB1</l> <ct name="/Interaction" s="1456" l="15"> <f>phosphorylation</f> <l>phosphorylation</l> </ct> <role name="OBJ" s="1475" l="15"> <f>Smad1 and Smad2</f> <l>Smad1 and SMAD2</l> <ct name="/BiologicalEntity" s="1475" l="5"> <f>Smad1</f> <l>Smad1</l> <role name="ProteinGene" s="1475" l="5"> <f>Smad1</f> <l>Smad1</l> </ct> <ct name="/BiologicalEntity" s="1485" l="5"> <f>Smad2</f> <l>SMAD2</l> <role name="LabelledProteinGene" s="1485" l="5"> <f>Smad2</f> <l>SMAD2</l> <ct name="/ProMiner/human/ENTREZGENE/4087" s="1485" l="5"> <f>Smad2</f> <l>SMAD2</l> </ct> <ct name="/ProMiner/human/SWISSPROT/SMAD2_HUMAN" s="1485" l="5"> <f>Smad2</f> <l>SMAD2</l> </ct> </ct> <role name="SUBJ" s="1494" l="62"> <f>bone morphogenic protein-7 and transforming growth factor-beta</f> <l>bone morphogenic protein-7 and TGFB1</l> <ct name="/BiologicalEntity" s="1494" l="26"> <f>bone morphogenic protein-7</f> <l>bone morphogenic protein-7</l> <role name="CellsAndTissues" s="1494" l="4"> <f>bone</f> <l>bone</l> <role name="ProteinGene" s="1499" l="21"> <f>morphogenic protein-7</f> <l>morphogenic protein-7</l> </ct> <ct name="/BiologicalEntity" s="1525" l="31"> <f>transforming growth factor-beta</f> <l>TGFB1</l> <role name="LabelledProteinGene" s="1525" l="31"> <f>transforming growth factor-beta</f> <l>TGFB1</l> <ct name="/ProMiner/human/ENTREZGENE/7040" s="1525" l="31"> <f>transforming growth factor-beta</f> <l>TGFB1</l> </ct> <ct name="/ProMiner/human/SWISSPROT/TGFB1_HUMAN" s="1525" l="31"> <f>transforming growth factor-beta</f> <l>TGFB1</l> </ct> </ct> <ct name="/CategoryRegulationOfActivation" s="0" l="0"> <f/> <l/> </ct> <ct name="/CategoryActivationOfRegulation" s="0" l="0"> <f/> <l/> </ct> <ct name="/CategoryInteraction" s="0" l="0"> <f/> <l/> </ct> <ct name="/CategoryBindingAndInteraction" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="1588" l="75"> <f>RGS4 selectively inhibits G protein and VEGF signaling in endothelial cells</f> <l>RGS4 selectively inhibit G|g protein and VEGF signal in endothelial cell</l> <role name="PROCESS" s="1588" l="75"> <f>RGS4 selectively inhibits G protein and VEGF signaling in endothelial cells</f> <l>RGS4 selectively inhibit G|g protein and VEGF signal in endothelial cell</l> <role name="SUBJ" s="1588" l="4"> <f>RGS4</f> <l>RGS4</l> <ct name="/BiologicalEntity" s="1588" l="4"> <f>RGS4</f> <l>RGS4</l> <role name="UnclassifiedBiologicalEntity" s="1588" l="4"> <f>RGS4</f> <l>RGS4</l> </ct> <role name="INTER" s="1593" l="20"> <f>selectively inhibits</f> <l>selectively inhibit</l> <ct name="/Inhibition" s="1605" l="8"> <f>inhibits</f> <l>inhibit</l> </ct> <role name="OBJ" s="1614" l="49"> <f>G protein and VEGF signaling in endothelial cells</f> <l>G|g protein and VEGF signal in endothelial cell</l> <role name="PROCESS" s="1614" l="49"> <f>G protein and VEGF signaling in endothelial cells</f> <l>G|g protein and VEGF signal in endothelial cell</l> <role name="OBJ" s="1614" l="18"> <f>G protein and VEGF</f> <l>G|g protein and VEGF</l> <ct name="/BiologicalEntity" s="1614" l="9"> <f>G protein</f> <l>G|g protein</l> <role name="ProteinGene" s="1614" l="9"> <f>G protein</f> <l>G|g protein</l> </ct> <ct name="/BiologicalEntity" s="1628" l="4"> <f>VEGF</f> <l>VEGF</l> <role name="ProteinGene" s="1628" l="4"> <f>VEGF</f> <l>VEGF</l> </ct> <ct name="/Regulation" s="1633" l="9"> <f>signaling</f> <l>signal</l> </ct> <ct name="/BiologicalEntity" s="1646" l="17"> <f>endothelial cells</f> <l>endothelial cell</l> <role name="CellsAndTissues" s="1646" l="17"> <f>endothelial cells</f> <l>endothelial cell</l> </ct> <ct name="/CategoryNegationOfRegulation" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="1688" l="46"> <f>RGS4 reduced endothelial cell response to VEGF</f> <l>RGS4 reduce endothelial cell response to VEGF</l> <role name="SUBJ" s="1688" l="4"> <f>RGS4</f> <l>RGS4</l> <ct name="/BiologicalEntity" s="1688" l="4"> <f>RGS4</f> <l>RGS4</l> <role name="UnclassifiedBiologicalEntity" s="1688" l="4"> <f>RGS4</f> <l>RGS4</l> </ct> <role name="INTER" s="1693" l="7"> <f>reduced</f> <l>reduce</l> <ct name="/Inhibition" s="1693" l="7"> <f>reduced</f> <l>reduce</l> </ct> <role name="OBJ" s="1701" l="25"> <f>endothelial cell response</f> <l>endothelial cell response</l> <ct name="/BiologicalEntity" s="1713" l="13"> <f>cell response</f> <l>cell response</l> <role name="CellsAndTissues" s="1713" l="4"> <f>cell</f> <l>cell</l> </ct> <role name="IndOBJ" s="1730" l="4"> <f>VEGF</f> <l>VEGF</l> <ct name="/BiologicalEntity" s="1730" l="4"> <f>VEGF</f> <l>VEGF</l> <role name="ProteinGene" s="1730" l="4"> <f>VEGF</f> <l>VEGF</l> </ct> <ct name="/CategoryInhibition" s="0" l="0"> <f/> <l/> </ct> </ct> <ct name="/EntityAndRelationship" s="1812" l="143"> <f>a novel antagonist of epithelial and endothelial cell tubulogenesis that selectively antagonizes intracellular signaling by G proteins and VEGF</f> <l>a novel antagonist of epithelial and endothelial cell tubulogenesis|tubulogenesi that selectively antagonize intracellular signal by G|g protein and VEGF</l> <role name="SUBJ" s="1812" l="67"> <f>a novel antagonist of epithelial and endothelial cell tubulogenesis</f> <l>a novel antagonist of epithelial and endothelial cell tubulogenesis|tubulogenesi</l> <role name="AGENT" s="1812" l="67"> <f>a novel antagonist of epithelial and endothelial cell tubulogenesis</f> <l>a novel antagonist of epithelial and endothelial cell tubulogenesis|tubulogenesi</l> <ct name="/Inhibition" s="1820" l="10"> <f>antagonist</f> <l>antagonist</l> </ct> <ct name="/BiologicalEntity" s="1861" l="18"> <f>cell tubulogenesis</f> <l>cell tubulogenesis|tubulogenesi</l> <role name="Process" s="1861" l="18"> <f>cell tubulogenesis</f> <l>cell tubulogenesis|tubulogenesi</l> </ct> <role name="INTER" s="1885" l="23"> <f>selectively antagonizes</f> <l>selectively antagonize</l> <ct name="/Inhibition" s="1897" l="11"> <f>antagonizes</f> <l>antagonize</l> </ct> <role name="OBJ" s="1909" l="46"> <f>intracellular signaling by G proteins and VEGF</f> <l>intracellular signal by G|g protein and VEGF</l> <role name="PROCESS" s="1909" l="46"> <f>intracellular signaling by G proteins and VEGF</f> <l>intracellular signal by G|g protein and VEGF</l> <ct name="/Regulation" s="1923" l="9"> <f>signaling</f> <l>signal</l> </ct> <role name="SUBJ" s="1936" l="19"> <f>G proteins and VEGF</f> <l>G|g protein and VEGF</l> <ct name="/BiologicalEntity" s="1936" l="10"> <f>G proteins</f> <l>G|g protein</l> <role name="ProteinGene" s="1936" l="10"> <f>G proteins</f> <l>G|g protein</l> </ct> <ct name="/BiologicalEntity" s="1951" l="4"> <f>VEGF</f> <l>VEGF</l> <role name="ProteinGene" s="1951" l="4"> <f>VEGF</f> <l>VEGF</l> </ct> <ct name="/CategoryNegationOfRegulation" s="0" l="0"> <f/> <l/> </ct> </ct> </concept-tokens>